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التصنيف: antiemetic
المادة الفعالة: ondansetron

Ondansetron is a selective 5-HT3 (serotonin) receptor antagonist used primarily as an antiemetic.
It works by blocking serotonin receptors located on vagal nerve terminals in the gastrointestinal tract and in the chemoreceptor trigger zone of the brain.
Chemotherapy, radiation, and surgical procedures can trigger serotonin release from enterochromaffin cells in the small intestine, activating the vomiting reflex.
By inhibiting 5-HT3 receptor activation, ondansetron suppresses the neural signals responsible for nausea and vomiting.
It is mainly indicated for prevention and treatment of chemotherapy-induced, radiotherapy-induced, and postoperative nausea and vomiting (CINV, RINV, and PONV).